Lack of evidence for linkage to chromosomes 13 and 8 for schizophrenia and schizoaffective disorder

Am J Med Genet. 2000 Apr 3;96(2):235-9. doi: 10.1002/(sici)1096-8628(20000403)96:2<235::aid-ajmg21>3.0.co;2-l.

Abstract

A previous report [Blouin et al., 1998: Nat Genet 20:70-73] suggesting linkage to chromosomes 13q32 and 8p21 in families with schizophrenia led us to investigate these regions in a large set of 301 multiplex families with schizophrenia. Multipoint analyses failed to reveal evidence for linkage to any portion of chromosome 13, while only a weakly positive score was present on 8p using the identical marker reported in the earlier report. Failure to confirm the Blouin et al claims in a substantially larger cohort adds emphasis to the inconsistency of the findings concerning linkage in schizophrenia. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:235-239, 2000.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosomes, Human, Pair 13 / genetics*
  • Chromosomes, Human, Pair 8 / genetics*
  • Genetic Linkage / genetics*
  • Genetic Markers / genetics
  • Genotype
  • Humans
  • Psychotic Disorders / genetics*
  • Schizophrenia / genetics*
  • Statistics, Nonparametric

Substances

  • Genetic Markers