[A case of Fisher syndrome showing pharyngeal-cervical-brachial weakness with an elevation of anti-GQ 1 b and anti-GT 1 a antibodies]

Rinsho Shinkeigaku. 2000 Feb;40(2):166-9.
[Article in Japanese]

Abstract

A 15-year-old boy developed ataxic gait, diplopia and hoarseness. Within 3 days after the onset, he had additional symptoms of dysphagia and dysarthria. He was admitted to our hospital 7 days after the onset of the disease. On admission, he had total ophthalmoplegia, ataxia, areflexia, facial diplegia, bulbar palsy and weakness of the neck and upper arms. Serum anti-GQ 1 b and anti-GT 1 a antibodies were significantly elevated. A diagnosis of Fisher syndrome associated with pharyngeal-cervical-brachial weakness was made. He was placed on a high dose of intravenous immunoglobins (12.5 g/day x 2 days) and had steroid pulse therapy (methylprednisolone 1 g x 3 days), which resulted in an almost complete recovery. There have been no reports of Fisher syndrome associated with brachio-pharyngeal-palsy. As in the case of the pharyngeal-cervical-brachial variant of Guillain Barré syndrome, anti-GT 1 a antibodies may be associated with Fisher syndrome with pharyngeal-cervical-brachial weakness.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adolescent
  • Arm
  • Autoantibodies / blood*
  • Gangliosides / immunology*
  • Humans
  • Male
  • Miller Fisher Syndrome / complications
  • Miller Fisher Syndrome / immunology*
  • Muscle Hypotonia / etiology*
  • Neck
  • Pharyngeal Muscles

Substances

  • Autoantibodies
  • Gangliosides
  • GQ1b ganglioside