[Low expression of nm23-H1 mRNA and its protein in breast cancer]

Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2000 Apr;17(2):91-3.
[Article in Chinese]

Abstract

Objective: To explore the expression of nm23-H1 mRNA and its protein in breast cancer and its correlation to the biologic behavior.

Methods: RT-PCR and immunohistochemical method were employed to detect the expression of nm23-H1 mRNA and its protein in 58 breast cancer tissues.

Results: Low level expression of nm23-H1 mRNA and protein was shown in 44.8% and 48.2% of examined cases respectively. The low expression of nm23-H1 mRNA was correlated, but not always parallel to the protein expression. The low level expression of nm23-H1 mRNA or the protein was significantly associated with lymphatic metastasis of the cancer.

Conclusion: Examination of nm23-H1 expression may be of significance in evaluating metastatic potentiality and prognosis of breast cancer.

Publication types

  • English Abstract

MeSH terms

  • Breast Neoplasms / genetics*
  • Female
  • Humans
  • Monomeric GTP-Binding Proteins / analysis
  • Monomeric GTP-Binding Proteins / genetics*
  • NM23 Nucleoside Diphosphate Kinases
  • Neoplasm Metastasis
  • Nucleoside-Diphosphate Kinase*
  • Prognosis
  • RNA, Messenger / analysis*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Transcription Factors / analysis
  • Transcription Factors / genetics*

Substances

  • NM23 Nucleoside Diphosphate Kinases
  • RNA, Messenger
  • Transcription Factors
  • NME1 protein, human
  • Nucleoside-Diphosphate Kinase
  • Monomeric GTP-Binding Proteins