Treatment of multifocal motor neuropathy with interferon-beta1A

Neurology. 2000 Apr 11;54(7):1518-21. doi: 10.1212/wnl.54.7.1518.

Abstract

Nine patients with multifocal motor neuropathy who had previously responded favorably to IV immunoglobulins (IVIg) were treated with interferon-beta1a. Muscle strength and disability were evaluated. In six patients there was no effect of treatment. Four patients deteriorated in such a way that IVIg had to be restarted during the study. Three patients showed an improvement that was more pronounced than on IVIg. These patients had a shorter disease duration and were less affected clinically and electrophysiologically than those who did not respond.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / drug effects
  • Adult
  • Age of Onset
  • Demyelinating Autoimmune Diseases, CNS / drug therapy*
  • Female
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use
  • Injections, Subcutaneous
  • Interferon beta-1a
  • Interferon-beta / therapeutic use*
  • Male
  • Middle Aged
  • Motor Neuron Disease / drug therapy*
  • Motor Neurons / drug effects
  • Motor Neurons / physiology
  • Muscle Contraction / drug effects
  • Neural Conduction / drug effects
  • Neurophysins
  • Peripheral Nerves / drug effects
  • Peripheral Nerves / physiopathology
  • Psychomotor Performance / drug effects
  • Treatment Outcome

Substances

  • Immunoglobulins, Intravenous
  • Neurophysins
  • Interferon-beta
  • Interferon beta-1a