N-myristoyltransferase

Mol Cell Biochem. 2000 Jan;204(1-2):135-55. doi: 10.1023/a:1007012622030.

Abstract

Myristoylation refers to the co-translational addition of a myristoyl group to an amino-terminal glycine residue of a protein by an ubiquitously distributed enzyme myristoyl-CoA:protein N-myristoyltransferase (NMT, EC 2.3.1.97). This review describes the basic enzymology, molecular cloning and regulation of NMT activity in various pathophysiological processes such as colon cancer and diabetes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acyl Coenzyme A / metabolism
  • Acyltransferases* / antagonists & inhibitors
  • Acyltransferases* / genetics
  • Acyltransferases* / isolation & purification
  • Acyltransferases* / metabolism
  • Adenocarcinoma / enzymology
  • Adenocarcinoma / metabolism
  • Animals
  • Calcium / metabolism
  • Calpain / metabolism
  • Colorectal Neoplasms / enzymology
  • Colorectal Neoplasms / metabolism
  • Enzyme Precursors / metabolism
  • Gene Expression Regulation, Enzymologic
  • Humans
  • Kinetics
  • Molecular Sequence Data
  • Oncogene Protein pp60(v-src) / metabolism
  • Protein Processing, Post-Translational

Substances

  • Acyl Coenzyme A
  • Enzyme Precursors
  • S-tetradecanoyl-coenzyme A
  • Acyltransferases
  • glycylpeptide N-tetradecanoyltransferase
  • Oncogene Protein pp60(v-src)
  • Calpain
  • mu-calpain proenzyme
  • Calcium