Requirement for homologous recombination functions for expression of the mutA mistranslator tRNA-induced mutator phenotype in Escherichia coli

J Bacteriol. 2000 Mar;182(5):1427-31. doi: 10.1128/JB.182.5.1427-1431.2000.

Abstract

Expression of the Escherichia coli mutA mutator phenotype requires recA, recB, recC, ruvA, and ruvC gene, but not recD, recF, recO, or recR genes. Thus, the recBCD-dependent homologous recombination system is a component of the signal pathway that activates an error-prone DNA polymerase in mutA cells.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Bacterial Proteins / genetics
  • DNA Helicases*
  • DNA-Binding Proteins / genetics
  • Endodeoxyribonucleases / genetics
  • Escherichia coli / genetics*
  • Escherichia coli / metabolism
  • Escherichia coli Proteins*
  • Exodeoxyribonuclease V
  • Exodeoxyribonucleases / genetics
  • Gene Expression Regulation, Bacterial
  • Genes, Bacterial / genetics*
  • Mutation
  • Phenotype
  • RNA, Transfer / biosynthesis*
  • Rec A Recombinases / genetics
  • Recombination, Genetic / physiology*
  • Signal Transduction

Substances

  • Bacterial Proteins
  • DNA-Binding Proteins
  • Escherichia coli Proteins
  • ruvC protein, E coli
  • RNA, Transfer
  • Rec A Recombinases
  • Endodeoxyribonucleases
  • Exodeoxyribonucleases
  • Exodeoxyribonuclease V
  • exodeoxyribonuclease V, E coli
  • Holliday junction DNA helicase, E coli
  • DNA Helicases