Current biology of VEGF-B and VEGF-C

B Olofsson; M Jeltsch; U Eriksson; K Alitalo

doi:10.1016/s0958-1669(99)00024-5

Current biology of VEGF-B and VEGF-C

Curr Opin Biotechnol. 1999 Dec;10(6):528-35. doi: 10.1016/s0958-1669(99)00024-5.

Authors

B Olofsson¹, M Jeltsch, U Eriksson, K Alitalo

Affiliation

¹ Ludwig Institute for Cancer Research, Box 240, Stockholm, SE-171 77, Sweden.

PMID: 10600689
DOI: 10.1016/s0958-1669(99)00024-5

Abstract

Endothelial growth factors and their receptors may provide important therapeutic tools for the treatment of pathological conditions characterised by defective or aberrant angiogenesis. Vascular endothelial growth factor (VEGF) is pivotal for vasculogenesis and for angiogenesis in normal and pathological conditions. VEGF-B and VEGF-C provide this gene family with additional functions, for example, VEGF-C also regulates lymphangiogenesis.

Publication types

Review

MeSH terms

Animals
Endothelial Growth Factors / chemistry
Endothelial Growth Factors / metabolism
Endothelial Growth Factors / physiology*
Humans
Ligands
Neovascularization, Physiologic / physiology
Receptor Protein-Tyrosine Kinases / metabolism
Receptors, Growth Factor / metabolism
Receptors, Vascular Endothelial Growth Factor
Signal Transduction
Vascular Endothelial Growth Factor B
Vascular Endothelial Growth Factor C

Substances

Endothelial Growth Factors
Ligands
Receptors, Growth Factor
Vascular Endothelial Growth Factor B
Vascular Endothelial Growth Factor C
Receptor Protein-Tyrosine Kinases
Receptors, Vascular Endothelial Growth Factor