The contribution of ER quality control to the biologic functions of secretory IgM

Immunol Today. 1999 Dec;20(12):582-8. doi: 10.1016/s0167-5699(99)01542-x.

Abstract

Secretory IgM provides a first line of defense against pathogens and is uniquely capable of enhancing the primary humoral immune response. Complement activation is especially important for these activities. Here, Padmalatha Reddy and Ronald Corley discuss how the 'quality control' mechanisms that regulate IgM assembly and secretion play important roles in the developmental progression of B cells and in B-cell function.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Agammaglobulinaemia Tyrosine Kinase
  • Animals
  • B-Lymphocytes / immunology
  • Complement Activation
  • Cysteine / chemistry
  • Immunoglobulin J-Chains / chemistry
  • Immunoglobulin J-Chains / immunology
  • Immunoglobulin M / chemistry
  • Immunoglobulin M / immunology*
  • Mice
  • Mice, Knockout
  • Plasma Cells / immunology
  • Protein-Tyrosine Kinases / deficiency
  • Protein-Tyrosine Kinases / physiology
  • Receptors, Estrogen / physiology*
  • Sulfhydryl Compounds / chemistry

Substances

  • Immunoglobulin J-Chains
  • Immunoglobulin M
  • Receptors, Estrogen
  • Sulfhydryl Compounds
  • secretory IgM
  • Protein-Tyrosine Kinases
  • Agammaglobulinaemia Tyrosine Kinase
  • Cysteine