An unusual case of intrapulmonary granulocytic sarcoma presenting as interstitial pneumonitis following allogeneic bone marrow transplantation for acute myeloid leukaemia and responding to donor lymphocyte infusion

P D Kottaridis; N Ketley; K Peggs; R Chakraverty; G Ralleigh; P Shaw; F Pezzella; A H Goldstone; S Devereux; S Mackinnon

doi:10.1038/sj.bmt.1701974

An unusual case of intrapulmonary granulocytic sarcoma presenting as interstitial pneumonitis following allogeneic bone marrow transplantation for acute myeloid leukaemia and responding to donor lymphocyte infusion

Bone Marrow Transplant. 1999 Oct;24(7):807-9. doi: 10.1038/sj.bmt.1701974.

Authors

P D Kottaridis¹, N Ketley, K Peggs, R Chakraverty, G Ralleigh, P Shaw, F Pezzella, A H Goldstone, S Devereux, S Mackinnon

Affiliation

¹ Department of Haematology, University College London Hospitals, UK.

PMID: 10516687
DOI: 10.1038/sj.bmt.1701974

Abstract

We report a 45-year-old female with AML who underwent a T cell-depleted sibling allograft and relapsed a year later with extramedullary disease involving the lung parenchyma and presenting with the clinical and radiological features of interstitial pneumonitis. The patient was treated with donor lymphocyte infusion (DLI) resulting in complete resolution of the radiological signs. The unusual presentation and the management options are discussed.

Publication types

Case Reports

MeSH terms

Bone Marrow Transplantation* / pathology
Diagnosis, Differential
Female
Humans
Leukemia, Myeloid / diagnosis*
Leukemia, Myeloid / pathology
Leukemia, Myeloid / therapy*
Lung Diseases, Interstitial / diagnosis*
Lung Diseases, Interstitial / pathology
Lung Diseases, Interstitial / therapy*
Lymphocyte Transfusion* / adverse effects
Middle Aged
Neoplasm Recurrence, Local