Structure-based design and synthesis of a novel class of Src SH2 inhibitors

J L Buchanan; R S Bohacek; G P Luke; M Hatada; X Lu; D C Dalgarno; S S Narula; R Yuan; D A Holt

doi:10.1016/s0960-894x(99)00388-1

Structure-based design and synthesis of a novel class of Src SH2 inhibitors

Bioorg Med Chem Lett. 1999 Aug 16;9(16):2353-8. doi: 10.1016/s0960-894x(99)00388-1.

Authors

J L Buchanan¹, R S Bohacek, G P Luke, M Hatada, X Lu, D C Dalgarno, S S Narula, R Yuan, D A Holt

Affiliation

¹ ARIAD Pharmaceuticals, Inc., Cambridge, Massachusetts 02139-4234, USA.

PMID: 10476868
DOI: 10.1016/s0960-894x(99)00388-1

Abstract

The structure-based design and synthesis of a novel class of 2,4-disubstituted thiazoles as Src SH2 inhibitors is described. Initial results are presented, including the X-ray and NMR analysis of one thiazole inhibitor bound to Lck and Src SH2.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Crystallography, X-Ray
Magnetic Resonance Spectroscopy
Molecular Structure
Thiazoles / chemical synthesis
Thiazoles / chemistry*
Thiazoles / pharmacology
src Homology Domains*

Substances

Thiazoles