Syntheses of (+/-)-shinflavanone and its structural analogues as potent inhibitors of bone resorption pits formation

Bioorg Med Chem Lett. 1999 May 17;9(10):1433-6. doi: 10.1016/s0960-894x(99)00212-7.

Abstract

The first total syntheses of (+/-)-shinflavanone and its structural analogues were achieved. (+/-)-Shinflavanone, appears to be a strong inhibitor of bone resorption pits formation by osteoclast-like cell induced by 1alpha, 25-dihydroxy vitamine D3 (IC50 = 0.70 microg/mL).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bone Resorption / prevention & control*
  • Calcitriol / pharmacology
  • Flavanones*
  • Flavonoids / chemical synthesis*
  • Flavonoids / chemistry
  • Flavonoids / pharmacology*
  • Molecular Structure
  • Osteoclasts / drug effects

Substances

  • Flavanones
  • Flavonoids
  • shinflavanone
  • Calcitriol