Correlation of tumor suppressor P53 RNA expression with human immunodeficiency virus disease in rapid and slow progressors

J Hum Virol. 1997 Nov-Dec;1(1):30-6.

Abstract

Objective: To determine the relation between P53 tumor suppressor RNA expression and human immunodeficiency virus (HIV) disease progression.

Study design/methods: A quantitative assay of P53 RNA expression was used to analyze a cohort of HIV-negative persons. The assay was then used in longitudinal and cross-sectional studies of HIV slow and rapid progressors.

Results: We demonstrate first that P53 expression in peripheral blood mononuclear cells from HIV-1-seronegative persons is minimal. Longitudinal studies in a small cohort of HIV-1-infected slow and rapid progressors reveal that rapid progressors seem to have greater P53 RNA expression over time. This was validated in a cohort of 26 HIV-1-infected persons in whom the expression of P53 RNA was significantly greater in persons with rapid progression of HIV-1 disease.

Conclusion: These data suggest that P53 RNA expression may play a role in the pathogenesis of HIV-1 disease, though the mechanism of this interaction remains unknown.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • CD4 Lymphocyte Count
  • CHO Cells
  • Cell Cycle
  • Cricetinae
  • Disease Progression
  • Gene Expression
  • Genes, Tumor Suppressor*
  • HIV Infections / blood
  • HIV Infections / genetics*
  • HIV Infections / immunology
  • HIV Infections / virology
  • HIV Seronegativity
  • HIV-1 / physiology
  • Humans
  • RNA, Messenger / analysis
  • Tumor Suppressor Protein p53 / analysis
  • Tumor Suppressor Protein p53 / blood
  • Tumor Suppressor Protein p53 / genetics*
  • Viral Load

Substances

  • RNA, Messenger
  • Tumor Suppressor Protein p53